SAN FRANCISCO (0-4) at INDIANAPOLIS (1-3)
Sunday, 1 p.m. EDT, Fox
OPENING LINE — Colts by 1
RECORD VS. SPREAD — 49ers 3-1, Colts 2-2
SERIES RECORD — Colts lead 25-18
LAST MEETING — Colts beat 49ers 27-7, Sept. 22, 2013
LAST WEEK — 49ers lost to Cardinals 18-15, OT; Colts lost to Seahawks 46-18
AP PRO32 RANKING — 49ers No. 31, Colts No. 30
49ERS OFFENSE — OVERALL (25), RUSH (18), PASS (24).
49ERS DEFENSE — OVERALL (19), RUSH (15), PASS (22).
COLTS OFFENSE — OVERALL (31), RUSH (25), PASS (29).
COLTS DEFENSE — OVERALL (31), RUSH (22), PASS (29).
STREAKS, STATS AND NOTES -- 49ers begin Week 5 as one of four winless teams in NFL. Last three losses have come by total of eight points. ... San Francisco has lost 11 of 12 road games since December 2015 and three straight in series against Colts. ... Last win over Indy, 40-21 in 2001, came on day Peyton Manning threw four interceptions, which led to Jim Mora's memorable "playoffs" postgame news conference. ... DE Elvis Dumervil leads active NFL players with 32 games with more than one sack but has none against Indy. ... K Robbie Gould has made all 11 field goal attempts this season and has made career-best 28 in row. ... RB Carlos Hyde ranks No. 6 in NFL with 409 yards from scrimmage. ... WR Pierre Garcon, who started career with Colts, enters game with 584 receptions. ... Indy has lost five straight against NFC West. ... Colts face winless team for third time in four weeks. ... After Manning's statue unveiling Saturday, he will become 14th member of Indy's Ring of Honor during halftime ceremony. ... Manning also will become first player of Indy era, eighth in franchise history, with retired number. ... RB Frank Gore needs 4 yards rushing to pass Eric Dickerson (13,259) and three carries to pass Edgerrin James (3,028) for No. 7 all-time on both lists. It will be Gore's first contest against former team. ... K Adam Vinatieri will tie Jason Hanson (327) for fifth-most games played in league history. Vinatieri needs four field goal attempts to tie George Blanda (639) for No. 3 all-time, and three field goals made to tie Gary Anderson (538) for second. ... WR T.Y. Hilton needs nine receptions for 400 in career. ... S Malik Hooker enters Week 5 with share of NFL lead in interceptions, picking off one each in last three games. ... Second-year CB Rashaan Melvin is tied for No. 3 in league with seven passes defensed. ... QB Andrew Luck returned to practice this week, but QB Jacoby Brissett is expected to make fourth straight start. ... Fantasy Tip: Gore is still going strong after 49ers let him walk in free agency four years ago. Though San Francisco is giving up 3.3 yards per carry, Gore might be worth taking risk on against former team.
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